| abstract |
The invention discloses a collagen membrane for assisting treatment of peripheral nerve injury, a preparation method thereof and use thereof. The collagen membrane is obtained by crosslinking an aqueous solution of collagen, a dilute acetic acid solution of chitosan, an aqueous solution of polyvinyl alcohol, a water-soluble nerve growth factor, an aqueous solution of B12, and polyethylene glycol by using glutaraldehyde. At present, the treatment of peripheral nerves is limited to neurotrophic drug-assisted support after microsurgical suture. This method will produce a certain tension on the peripheral nerve end, which is not conducive to the repair of the broken end. The invention can overcome the problem of tension generated by the peripheral nerve endings and the degradation of the collagen membrane in the early recovery can promote the recovery of the peripheral nerves, can restore its basic motor function in a short time, and is more than the single end of the nerve bundle Membrane suture or end-to-end nerve bundle epithelial suture combined with nerve fusion agent is more effective. |