| abstract |
The invention relates to a microemulsion containing nattokinase and a preparation method thereof. The microemulsion comprises 2%-12% of nattokinase lyophilized powder, 5%-20% of oil phase solvent, 10%-20% of polyphenolic emulsifier, 5%-10% of co-emulsifier, and the balance is deionized. The sum of water and raw materials is 100%. The preparation method comprises the following steps: firstly dissolving the nattokinase lyophilized powder and the co-emulsifier in water to prepare an aqueous phase, and then stirring the oil phase solvent and the polyphenol emulsifier uniformly under heating to form an oil phase, and finally The oil phase is slowly added to the water phase, and stirred while stirring to form a uniform emulsion. The microporous membrane is filtered, sterilized, and packaged. The invention reduces the degradation inactivation of nattokinase before reaching the small intestine by making the nattokinase into a microemulsion, thereby being better absorbed by the human body and improving the bioavailability of the drug. |