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filingDate 2017-07-13-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109251492-B
titleOfInvention Bioink and its preparation method and application
abstract The invention provides a biological ink, the components of which include synthetic degradable polymers, natural macromolecules and solvents. The bioink of the present invention may also contain fluorescently modified natural polymers. The invention also provides a tissue engineering scaffold printed by the biological ink. The composite bio-ink formed by blending in the present invention has the advantages of both synthetic polymers and natural polymers, so that the scaffold formed by the ink 3D printing has sufficient mechanical strength, controllable cell affinity and degradability ; Fluorescence intensity changes of scaffolds with fluorescent properties can also be used to assess the degradation degree of scaffolds in real time. The present invention also provides a method for preparing a fluorescently labeled protein, and a bioink comprising the fluorescently labeled protein prepared according to the method.
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