| abstract |
The invention discloses a preparation method of 3-position or 4-position trifluoromethyl substituted isocoumarin, which adopts various substituted benzoic acids and trifluoromethyl phenylacetylene as reaction substrates. The reaction yield can reach medium to excellent, the chemical selectivity of the reaction is excellent, the reaction conditions are mild, and the substrate is suitable for a wide range (wherein R=H or groups such as CH 3 , OCH 3 , and thiophene heterocycles, etc.; Ar= various substituted benzene rings); its simple operation, low cost, few side reactions, high product purity, easy separation and purification and can be applied to larger-scale preparation, so the product obtained has a very good quality in the field of biomedicine. application prospects. |