http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109232695-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J5-0092 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J5-00 |
| filingDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109232695-B |
| titleOfInvention | Preparation method of 16a, 21-diacetyl oxygen prednisolone |
| abstract | The invention provides a preparation method of 16a, 21-diacetyl oxygen group prednisolone, which comprises the steps of adopting 17 a-dehydroxy prednisolone acetate as a raw material, firstly, carrying out epoxidation reaction on the starting raw material 17 a-dehydroxy prednisolone acetate and organic peroxy acid at 16,17 positions in a first organic solvent to prepare an epoxy substance; and reacting the epoxy compound with glacial acetic acid in a second organic solvent under the catalysis of an acid catalyst for ring opening to obtain the target product 16a, 21-diacetyl oxygen prednisolone. The intermediate 16a, 21-diacetyl oxygen group prednisolone of the 16 alpha-hydroxy prednisolone is prepared by an efficient, environment-friendly and flat method. |
| priorityDate | 2018-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.