| abstract |
The invention provides a method for purifying everolimus. The everolimus is derivatized, separated and then hydrolyzed, and the content of the impurity rapamycin in the obtained everolimus after the treatment is greatly reduced. Further, a product with higher purity can be obtained in a higher yield through one-time preparation of liquid-phase purification, thereby reducing the industrial cost of the purification step; the present application further provides a preparation method of everolimus, which has high yield and is easy to operate. Simple and suitable for industrial production. |