http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109180702-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D519-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D519-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109180702-B |
| titleOfInvention | Thienopyrimidone compound and application thereof |
| abstract | The invention belongs to the field of chemical medicine, and particularly relates to a thienopyrimidinone compound, which has a structural formula as follows: the invention synthesizes a novel thienopyrimidinone compound, proves that the compound can generate better inhibiting effect on Tankyrase without obvious toxic effect, and after STF3A cells are treated by the compound, the compound can obviously inhibit the proliferation of tumor cells, has good medicinal potential and provides a new potential choice for clinical medication; the novel thienopyrimidinone compound can enhance the expression level of axial protein in a wnt signal pathway and induce the degradation of beta-catenin, thereby inhibiting the proliferation of tumor cells, can be used as a clinical prodrug candidate compound of various tumor cells, and has the potential of further research and development; the novel thienopyrimidone compound is also provided, and the preparation method can obtain the compound with higher yield and high biological activity, so that the compound has obvious drug property and wide market prospect. |
| priorityDate | 2018-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 100.