http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109180680-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C09B23-086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C09B23-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate | 2018-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109180680-B |
| titleOfInvention | Ultraviolet light triggered crosslinking near-infrared molecular probe and preparation method and application thereof |
| abstract | The invention discloses a photo-crosslinking near-infrared molecular probe and a preparation method and application thereof. Specifically, the preparation method comprises the following steps: constructing and synthesizing a photo-crosslinking near-infrared molecular probe DACF; the photo-crosslinking near-infrared molecular probe DACF is crosslinked in cells under the trigger of ultraviolet light. The probe disclosed by the invention is irradiated by light with a specific wavelength to generate a high-activity carbene intermediate which is combined with a covalent bond of a biomolecule in a cell, so that the uptake of the probe in the cell is remarkably increased, the retention time of the probe is prolonged, and the long-time tracking of tumor cells can be realized. Meanwhile, the photo-thermal effect of the probe can be utilized to better kill tumor cells. The photo-crosslinking near-infrared molecular probe obtained by the preparation method can effectively improve the enrichment amount and retention time of the probe in the living tumor, realizes the diagnosis and treatment integration of the tumor, and has important scientific research and economic values. |
| priorityDate | 2018-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 55.