| abstract |
The invention discloses iminothiadiazine dioxide derivatives and application thereof, and particularly relates to novel iminothiadiazine dioxide derivatives and a pharmaceutical composition containing the same, which can be used as a BACE-1 inhibitor. The invention also relates to processes for preparing such compounds and pharmaceutical compositions, and their use in the preparation of medicaments for the treatment of diseases associated with beta-amyloid (' a β '), in particular alzheimer's disease. |