http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109172598-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_780926f15181377d2d3befc5698175ce |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate | 2018-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_963126a037441b7d8500f69bd2dbd8d5 |
| publicationDate | 2019-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109172598-A |
| titleOfInvention | A kind of bone disease key microRNA's facilitates bone application method |
| abstract | The invention belongs to bone disease technical field, in particular a kind of bone disease key microRNA's facilitates bone application method, including the following contents: the hprt minigene acid of unconventionality expression, the microRNA are hsa-microRNA-196a in S1, Fracture Nonunion disease；S2, microRNA expression quantity under morbid state change, and the Fracture Nonunion patients blood plasma hsa-microRNA-196a that changes into is in obvious low expression；To medical diagnosis on disease feasibility analysis, it is Fracture Nonunion genius morbi microRNA that the analysis, which is hsa-microRNA-196a, by S3, microRNA, has good specificity and sensitivity；The regulation of S4, microRNA to Osteoblast Differentiation；S5, microRNA interfere downstream gene expression.The present invention is based on total 130 clinical normal populations and Fracture Nonunion blood sample of patient sheets, the detection and comparison of microRNA are carried out in conjunction with the past result of study and pertinent literature, obtain hsa-microRNA-196a Fracture Nonunion patient blood plasma expression quantity significantly lower than normal population, only 1/200. |
| priorityDate | 2018-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 119.