http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109161577-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-001 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-935 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-04 |
| filingDate | 2018-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109161577-B |
| titleOfInvention | Levo Corey lactone diol intermediate, preparation method and pharmaceutical application thereof |
| abstract | A levo-Corey lactone diol intermediate, a preparation method and a pharmaceutical application thereof, wherein the method for preparing the levo-Corey lactone diol intermediate comprises the steps of mixing an alkaline buffer solution containing esterase and a hydrophobic organic solvent for reaction; the hydrophobic organic solvent contains a vinyl carboxylate compound and a racemic compound I; the organic layer was separated from the reaction system, and the levorotatory compound VI was extracted from the organic layer. The invention can directly prepare the levorotatory compound VI by resolving the racemic compound I by esterase, and has the advantages of mild reaction conditions, no use of amine compounds, environmental friendliness, high enantiomeric excess value, high enantiomeric yield and the like. |
| priorityDate | 2018-09-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 71.