| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd1d45c56b55b594ab8ab2f25b4961b2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-24 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-62 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-36 |
| filingDate |
2017-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceda51ef0af7ef80c8615636087e23ea
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f004e560481fdfcdb27907cc446acec3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b61ecfac4d853cb4c5898481cf0faa2 |
| publicationDate |
2019-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109153726-A |
| titleOfInvention |
Monoclonal antibodies against the active site of factor XI and uses thereof |
| abstract |
The present invention provides novel anti-factor XI (FXI) antibodies and compositions comprising these antibodies. The anti-FXI antibody of the present invention specifically binds to the active center of FXI and inhibits the functional activity of FXI. The present invention further provides humanized forms of anti-FXI antibodies useful in the prevention and treatment of conditions involving pathological thrombosis or thromboembolism-related conditions. The present invention also provides nucleic acid molecules encoding anti-FXI antibodies, cells expressing anti-FXI antibodies, and methods of producing anti-FXI antibodies. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110423278-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021022676-A1 |
| priorityDate |
2016-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |