http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109134569-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate | 2018-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109134569-B |
| titleOfInvention | A kind of production technology of Vidarabine Monophosphate |
| abstract | The invention belongs to Vidarabine Monophosphate preparation technical fields, and in particular to a kind of production technology of Vidarabine Monophosphate, the technique include the following steps: that arabinosy ladenosine is dissolved in organic solvent by S1, cooling；Phosphoryl chloride phosphorus oxychloride is added in S2, and insulation reaction to arabinosy ladenosine surplus stops when being no more than the 3% of additional amount；S3 is filtered after palladium catalyst catalysis reduction is added, and gained filtrate is removed solvent up to Vidarabine Monophosphate crude product；The Vidarabine Monophosphate crude product recrystallization purifying that S4 obtains step S3.It is reacted using the relatively low phosphoryl chloride phosphorus oxychloride of the production technology reference reactivity of Vidarabine Monophosphate provided by the invention with raw material arabinosy ladenosine, reaction is mild, and it is easy to control, the generation quantity of by-product is reduced from reaction source；And the ether of introducing is restored using novel palladium catalyst selectivity, purifying process is simple, target product yield and purity is high. |
| priorityDate | 2018-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.