| abstract |
The invention discloses a kind of preparation methods of alkannin liposome gel, steps are as follows: by Shikonin, lecithin and cholesterol are added in dehydrated alcohol, and it is at the uniform velocity added in phosphate buffer solution by syringe, after keeping the temperature 40-50min, solution is placed on rotary evaporator, organic solvent is removed under reduced pressure, surplus solution is in 45-55 DEG C of heat preservation 1.5-2.5h, it is ultrasonic after cooling, filter to obtain alkannin liposome；Carbomer-940 is dissolved in deionized water, is swollen it sufficiently；By methyl p-hydroxybenzoate, borneol and Mentholum are dissolved in dehydrated alcohol, and are added in the gel-type vehicle being swollen, and glycerine, Tween-80 is then added, is eventually adding liposome, stirs evenly, with triethanolamine adjust pH value be 7.5-7.7 to get.The homogeneous exquisiteness of alkannin liposome gel of this method preparation, stretchability is good, has good stability, and has certain slow releasing function. |