| abstract |
The present invention provides a compound having an inhibitory activity against cell necrosis. The compound with the cell necrosis inhibitory activity, or a stereoisomer, a hydrate, an ester, a solvate, a co-crystal, a metabolite and a pharmaceutically acceptable salt thereof has a structure shown in a general formula I: the present invention also provides a pharmaceutical composition comprising the above-mentioned compound having a cell necrosis-suppressing activity or a derivative thereof. The invention also provides application of the compound and the derivative with the cell necrosis inhibitory activity in preparing medicines for treating and preventing systemic inflammatory response diseases, tumors, metabolic diseases and neurodegenerative diseases related to cell necrosis, such as cerebral ischemia and stroke. The compound having a cell necrosis-inhibiting activity of the present invention and the composition related thereto can effectively inhibit cell necrosis. |