http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109106712-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-366 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-366 |
| filingDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109106712-B |
| titleOfInvention | Application of brevifolin methyl phenolic acid in preparation of anti-influenza virus medicine |
| abstract | The invention discloses application of brevifolin methyl phenolic acid in preparation of anti-influenza virus drugs. The inventor finds that the brevifolin phenolic acid A is prepared by experimentsThe ester shows stronger anti-influenza A virus H1N1 subtype effect in the range of 0.78-100 mu g/mL and IC thereof 50 A value of 18.90 + -5.65 μmol/L, and a control drug of ribavirin (IC) 50 0.56 ± 1.10 μmol/L) was slightly lower. The result of the plaque experiment shows that the brevifolin methyl ester has an inhibitory effect on the plaque formed by MDCK cells (canine kidney epithelial cells) caused by H1N1 virus and has concentration dependence. The brevifolin methyl ester can inhibit the expression of virus NP protein and PB2 polymerase in MDCK cells, and the inhibition effect is enhanced along with the increase of the concentration. At the same time, methyl hematoxylin has inhibitory effect on H3N2, and its IC 50 ＝71.74±1.48μg/ml。 |
| priorityDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 247.