http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109097335-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0695 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 |
| filingDate | 2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2022-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2022-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109097335-B |
| titleOfInvention | Induction method for malignant transformation of normal hepatic stem cells to liver cancer stem cells |
| abstract | The invention belongs to the technical field of malignant transformation of liver stem cells, and discloses a method for inducing the malignant transformation of normal liver stem cells to liver cancer stem cells. The four transcription factors are TG737, miR10b, miR200a and CD44, respectively. The present invention realizes the malignant transformation of normal liver stem cells into liver cancer stem cells by silencing TG737, overexpressing MiR-10b, silencing miR-200a and overexpressing CD44, so that the induction method of the present invention can provide an experimental model for the study of liver cancer, Conducive to the study of liver cancer. |
| priorityDate | 2018-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 191.