http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109096404-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2740-15043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-70503 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-86 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0646 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K35-17 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K35-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-867 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109096404-B |
| titleOfInvention | Chimeric co-stimulatory transduction receptor, coding gene, recombinant expression vector, anti-tumor NK cell, and preparation method and application thereof |
| abstract | The invention relates to a chimeric co-stimulatory transduction receptor, a coding gene, a recombinant expression vector, an anti-tumor NK cell, a preparation method and an application thereof, and belongs to the technical field of tumor immune cell therapy. The chimeric costimulatory switching receptor comprises PD1 extracellular segment (1-170 aa), DAP10 extracellular, transmembrane and intracellular segment (19-93 aa) and costimulatory molecule 41BB intracellular segment (214-255 aa), DAP10 does not contain a signal peptide which influences transmembrane, but comprises an extracellular domain which contains glycosylation sites and can recruit free NKG2D, so that the activation of NK cells is greatly enhanced. According to the chimeric costimulation transformation receptor, the coding gene and the recombinant expression vector can be obtained, and the recombinant expression vector is transferred into NK cells, so that the anti-tumor NK cells can be obtained and have extremely high cytotoxicity. |
| priorityDate | 2018-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 190.