http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109096348-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H9-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H9-02 |
| filingDate | 2018-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109096348-B |
| titleOfInvention | Preparation method of fondaparinux sodium monosaccharide intermediate |
| abstract | The invention discloses a preparation method of fondaparinux sodium monosaccharide intermediate, which comprises the following steps: (1) in the presence of an acid binding agent, carrying out esterification reaction on the compound shown in the formula (I) and substituent sulfonic anhydride and/or substituent sulfonyl halide to generate a compound shown in a formula (II); (2) carrying out a ring opening reaction on the compound shown in the formula (II) under an acidic condition to generate a compound shown in a formula (III); (3) carrying out benzylation reaction on the compound shown in the formula (III) and benzyl monohalide under alkaline conditions to generate a compound shown in the formula (IV); (4) carrying out an azide reaction on the compound shown in the formula (IV) and an alkali metal azide salt to generate a compound shown in the formula (V), and carrying out an diether ring-opening and acetylation reaction on the compound shown in the formula (V) in a mixed solution of acetic anhydride and trifluoroacetic acid to generate a compound shown in the formula (VI); the method of the invention can obtain ideal product yield, and has the advantages of cheap and easily obtained raw materials and less three wastes. |
| priorityDate | 2018-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 187.