http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109096136-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C229-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-40 |
| filingDate | 2018-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109096136-B |
| titleOfInvention | Erlotinib intermediate compound and refining method thereof |
| abstract | The invention relates to an erlotinib intermediate compound and a refining method thereof, belonging to the technical field of medicines. The erlotinib intermediate compound is 2-amino-4, 5-di (2-methoxyethoxy) ethyl benzoate hydrochloride. The refining method comprises 5 steps: 1. dissolving the intermediate compound crude product in water, adding alumina for adsorption after dissolving, and filtering to remove the alumina; 2. adding isopropyl acetate into the filtrate obtained in the step 1, adding solid alkali to adjust the pH value to 7-8, stirring, standing, and layering; 3. adding the organic phase obtained in the step 2 into active carbon for decoloring, precisely filtering the active carbon, and evaporating part of isopropyl acetate under reduced pressure; 4. adding methanol into the distillation residual liquid in the step 3, dropwise adding thionyl chloride, stopping dropwise adding when the pH value is detected to be qualified, and continuously stirring; 5. and (4) cooling, then carrying out suction filtration, leaching the organic solvent, and drying to obtain a target product. The refining method is scientific and reasonable, has high recovery rate and is easy for industrial production. |
| priorityDate | 2018-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.