http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109081856-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F17-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109081856-B |
| titleOfInvention | 4-ferrocenyl-6-aryl-2-aminopyrimidine compound and preparation method thereof |
| abstract | The invention discloses a preparation method for preparing 4-ferrocenyl-6-aryl-2-aminopyrimidine, which comprises the following steps: adding the formula amount of ferrocenyl chalcone (A) into a reaction vessel, and fully stirring and dissolving methanol which is used as a solvent at room temperature; then adding guanidine hydrochloride (B) and alkali (C) with formula amount, slowly heating to reflux temperature, and monitoring by TLC until the reaction is finished; adding a proper amount of water into the reaction system, stirring uniformly, standing, separating liquid, drying an organic phase by using anhydrous magnesium sulfate, filtering, and performing rotary evaporation to obtain a crude product; the crude product is purified by column chromatography, and the yield can reach more than 70 percent; wherein A, B and C are 1: (4-6): (4-9). The invention also researches the antitumor activity of the compound, and experiments show that the compound has certain inhibitory activity on PC-3 cells of prostate cancer, and the obtained product has certain application prospect in the field of anticancer. |
| priorityDate | 2018-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.