http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109081840-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2018-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-04-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109081840-B |
| titleOfInvention | Preparation method of 5-bromo-7-azaindole |
| abstract | The invention belongs to the technical field of preparation of medical intermediates, and particularly relates to a preparation method of a medical intermediate 5-bromo-7-azaindole, which takes 2-aminopyridine as a raw material, obtains 5-bromo-2-aminopyridine through bromination reaction, obtains sulfate of 5-bromo-3-iodo-2-aminopyridine through iodination reaction, obtains 5-bromo-3-alkynyl-2-aminopyridine through Sonogashira coupling and deprotection reaction, and finally obtains a target product 5-bromo-7-azaindole through intramolecular cyclization reaction. The method has the advantages of low cost, easily obtained raw materials, easily realized reaction conditions, simple operation and the like, and the purity of the 5-bromo-7-azaindole product prepared by the method reaches over 99.3 percent. |
| priorityDate | 2018-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 97.