http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109071579-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-30 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-572 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-572 |
| filingDate | 2017-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109071579-B |
| titleOfInvention | Method for producing monomer for single-stranded nucleic acid molecule |
| abstract | The compound represented by the formula (2) or an enantiomer thereof is produced by reacting a compound represented by the formula (1) or an enantiomer thereof with 6-hydroxyhexanoic acid in a solvent in the presence of an additive such as 1-hydroxybenzotriazole and a condensing agent, mixing the obtained reaction mixture with water and a base such as an alkali metal hydroxide, and reacting the obtained compound represented by the formula (2) or an enantiomer thereof with 2-cyanoethyl N, N, N ', N' -tetraisopropyl phosphorodiamidate in the presence of a coupling activator such as diisopropylamine tetrazolium salt and in a solvent, whereby the compound represented by the formula (3) or an enantiomer thereof can be obtained as a monomer for producing a single-stranded nucleic acid molecule capable of inhibiting the expression of a target gene. |
| priorityDate | 2016-04-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 163.