| abstract |
The present invention relates to a new and efficient process for the preparation of a class of molecules, namely bicyclo [1.1.1] pentane and derivatives thereof, by reaction of [1.1.1] prop ane with various reagents under irradiation and/or in the presence of a free radical initiator to give bicyclo [1.1.1] pentane which is asymmetrically substituted in the 1 and 3 positions, which bicyclo [1.1.1] pentane may be used as an intermediate for the preparation of asymmetric 1, 3-disubstituted bicyclo [1.1.1] pentane derivatives and various physiologically active substances or materials containing these structures. |