| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_557e257f7cfcfb21577689883be97322
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6a02757a65a91dff318c09e775176b0d |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-06 |
| filingDate |
2018-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_14ea3485daec340b33518178d6bc0e74
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bc16b4776e1074ad20374381d2f74e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e15a68f2f7ebb8bc3888e033fa18f649
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e9e6a3895d4106dc8bf14420fbe45ec |
| publicationDate |
2018-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
CN-109053839-A |
| titleOfInvention |
Novel preparation method of nucleoside modified 3'-O-CH2N3-2'-O-Me-cytidine nucleoside |
| abstract |
The invention relates to a novel preparation method of nucleoside modified 3'-O-CH 2 N 3 -2'-O-Me-cytidine nucleoside. The method of the present invention uses the natural nucleoside modified 2'-O-Me-N 4 -Bz-cytidine nucleoside as a raw material, first reacts with a silylating agent, and silylates the 5'-OH; Anhydride reaction yields intermediate 3'‑O‑CH 2 SCH 3 ‑2'‑O‑Me‑N 4 ‑Bz‑cytidine; subsequent treatment with sulfuryl chloride yields key intermediate 3'‑O‑CH 2 Cl ‑2'‑O‑Me‑N 4 ‑Bz‑cytidine nucleoside; then through azide substitution, deprotection and other processes, high yield and high selectivity to generate the desired new nucleoside modification 3'‑ O ‑ CH2N3‑2' ‑O‑Me‑cytidine. The method of the invention is simple and economical and can realize large-scale production. |
| priorityDate |
2018-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |