| abstract |
The invention discloses a kind of hypochlorous acid near infrared fluorescent probe and its preparation method and application based on silicon rhodamine, belongs to technical field of analytical chemistry.Technical solution of the present invention main points are as follows: a kind of hypochlorous acid near infrared fluorescent probe based on silicon rhodamine, structural formula are as follows: The invention further particularly discloses the preparation method of the hypochlorous acid near infrared fluorescent probe based on silicon rhodamine and its hypochlorous applicable cases of selective enumeration method in water environment, cell system, mouse inflammatory model.The cyclization site that fluorescence probe of the invention is mediated using HClO specificity is as sound position mechanism, have the characteristics that near infrared emission, high sensitivity, selectivity are good, response is rapid, good light stability, the detection of highly selective and high sensitivity and imaging that can be used for HClO in biosystem, provide theoretical foundation and technical support to seek in life entity HClO with physiology or being associated with for pathogenesis. |