http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109053593-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109053593-B |
| titleOfInvention | 1- (2, 6-chlorphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof |
| abstract | The invention discloses 1- (2, 6-dichlorophenyl) -3- (6- (substituted anilino)) Pyrimidine-4-yl) urea compounds, and preparation methods and applications thereof. The compound has a structure shown in formula (I), has no toxic effect on proliferation of BEAS-2B cells (lung normal cells), has certain inhibition effect on five selected non-small cell lung cancer cell lines including A549 cells (WT EGFR), PC-9 cells (EGFR del E746-A75), H520 cells (FGFR amplification), H1581 cells (FGFR amplification) and H226 cells, shows certain antitumor activity, and can be used as an effective EGFR/FGFR inhibitor. |
| priorityDate | 2018-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.