| abstract |
The invention discloses a substituted azabenzanthrone compound and its application, which has the structure shown in formula I. Wherein, R 1 , R 2 , R 3 , R 4 substituents are independently selected from H, halogen, -CF 3 , -CN, -NO 2 , -OH, -NH 2 , -L-C1-C6 alkyl, -L-C1-C6 alkenyl, -L-substituted or unsubstituted heteroaryl, or -L-substituted or unsubstituted aryl, wherein L is a bond, O, S, -S(=O), One or more of ‑S(=O) 2 , NH, C(O), CH 2 , ‑NHC(O)O, ‑HC(O) or ‑C(O)NH; X is O, S , Se; Y is -CH2- , -NH-, -O-; Z is -CH2- , -NH-; n is 1-18. The compound can effectively block cell autophagy and can be used as an autophagy inhibitor; at the same time, it has good inhibitory activity and can be used in the preparation of drugs for treating tumors. |