http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109053496-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C231-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C269-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C67-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C271-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C269-06 |
| filingDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109053496-B |
| titleOfInvention | Synthetic method of 3-Boc-aminomethyl cyclobutanone |
| abstract | The invention relates to aA method for synthesizing 3-Boc-aminomethyl cyclobutanone. Mainly solves the technical problems of high raw material cost and troublesome post-treatment of the existing synthetic method. The synthesis method comprises the following steps: reacting 3-oxocyclobutanecarboxylic acid with trimethyl orthoformate in a methanol solution to generate a compound 1; reacting the compound 1 with benzylamine in methanol solution under the action of sodium methoxide to generate a compound 2; reacting the compound 2 with red aluminum in a tetrahydrofuran solution to generate a compound 3; in a methanol solution, Pd/C is added for hydrogenation and debenzylation of the compound 3 to obtain a compound 4; compound 4 in methanol solution, and Boc 2 O reacts to generate a compound 5; the compound 5 is reacted in 0.05M hydrochloric acid solution to produce the target compound 6. A series of gamma-butyrolactone derivatives, including some spiro derivatives, which are inhibitors with good biological activity, can be obtained by carrying out enzyme catalytic de-glandation on the corresponding prochiral 3-substituted cyclobutanone. |
| priorityDate | 2018-08-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.