http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109044978-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1641 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-56 |
| filingDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109044978-B |
| titleOfInvention | Preparation method and application of oleanolic acid nanoparticles |
| abstract | The invention discloses a method for preparing oleanolic acid nano-scale particles with special morphology by esterification modification of polyethylene glycol aligned oleanolic acid and a self-assembly mode, which comprises the steps of firstly dissolving oleanolic acid, methoxy polyethylene glycol amine, dicyclohexylcarbodiimide and 4-dimethylaminopyridine in dichloromethane, and stirring at room temperature; then transferring the reaction system into a dialysis bag, and dialyzing with water; and finally, freeze-drying the product obtained after dialysis to obtain the oleanolic acid nanoparticles OA-PEG 2000. The oleanolic acid nanoparticles prepared by the method can improve the water solubility of oleanolic acid, further improve the bioavailability of the oleanolic acid, and can be widely used for inhibiting the proliferation of tumor cells. |
| priorityDate | 2018-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 40.