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classificationCPCAdditional http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2021-258
classificationCPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N21-25
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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N23-2251
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filingDate 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-109030455-B
titleOfInvention Preparation and detection method of surface Raman enhanced substrate based on microchip
abstract A preparation and detection method of a surface Raman enhanced substrate based on a microchip comprises the following steps: selecting a glass sheet with micron scale to manufacture a microchip as a reaction carrier; the method comprises the following steps of taking a gold nanorod as a surface-enhanced Raman scattering substrate, and specifically preparing the gold nanorod according to the reaction requirement between the gold nanorod and a Raman reporter molecule to be combined; combining the gold nanorods with the micro-sheets forming the reaction carrier to obtain enhanced substrate micro-sheets-gold nanorods; selecting p-toluene thiophenol or 4-hydroxythiophenol or dinaphthol as Raman reporter molecules; and combining the microchip-gold nanorods with Raman reporter molecules to obtain the microchip-gold nanorods-Raman reporter molecules. The invention has the advantages of the Raman enhancement substrate based on the microsphere carrier, can enhance the signal intensity to a great extent, and has good application prospect in the fields of biomolecule analysis and the like.
priorityDate 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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