| abstract |
The invention discloses a kind of molecular markers of cancer of the esophagus, are the expression product of FXR1 gene and/or FXR1 gene.The significantly high expression in human esophageal carcinoma of FXR1 gene can be used for esophagus cancer diagnosis as the molecular marker of the cancer of the esophagus；Highly expressed FXR1 gene and the poor prognosis of Patients With Carcinoma of Esophagus and the DISTANT METASTASES IN of the cancer of the esophagus are closely related, prompt FXR1 gene that can provide effective information as the prognostic marker of the cancer of the esophagus for the DISTANT METASTASES IN diagnosis of the cancer of the esophagus, prognosis evaluation, therapeutic effect monitoring.The invention discloses the expression inhibiting agent of FXR1 gene, including siRNA and/or shRNA, and in the expression inhibiting for FXR1 gene, interference effect is good, the application potential with clinical gene therapy.The invention discloses stablizing to strike the cell strain for subtracting FXR1 gene, it is the esophageal cancer cell of FXR1 gene stable low-expression, is advantageously implemented the further research to FXR1 gene function. |