http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109021068-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 |
| filingDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109021068-B |
| titleOfInvention | Linear pseudo-polypeptide, preparation method thereof and application thereof in antibacterial drugs |
| abstract | The invention discloses a linear pseudopolypeptide, a preparation method thereof and application thereof in antibacterial drugs. The linear pseudopolypeptide comprises biological isoelectroforms of Loloatin C pharmacore sequence structure, namely biological isoelectroforms comprising Tyr, Pro, Trp and Phe, and four amino acid residues are in L-configuration or D-configuration, so that the linear pseudopolypeptide has more stable structure and higher stability in plasma. The linear pseudopolypeptide is prepared by a solid-phase synthesis method, and the total yield is 25-35%. The preparation method of the linear pseudo polypeptide has the advantages of mild reaction conditions, easy automation, simple and safe operation, high product purity and high total yield, and the prepared linear polypeptide can be used for preparing antibacterial drugs, particularly drugs for treating gram-positive bacteria or gram-negative bacteria infection, and has the advantages of high efficiency, broad spectrum and difficult generation of drug resistance. |
| priorityDate | 2018-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.