http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109021028-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3935357f2393110e9394b6233f8fccb3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F15-0046 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 |
| filingDate | 2018-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7ece37bef7f4c9d7d628be8f4aa337d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea389c8012498bcbf6b7d0d502957a15 |
| publicationDate | 2018-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109021028-A |
| titleOfInvention | Organic ruthenium complex and preparation method thereof and application in preparation of anti-tumor drugs |
| abstract | The invention discloses a kind of organic ruthenium complexes and preparation method thereof, the following steps are included: hydrate ruthenium trichloride and γ-terpinene is taken to be dissolved in ethyl alcohol, return stirring, obtain chemical compounds I, 2-mercaptobenzimidazole and 7- bromo-indazole is taken to be added in carbon tetrachloride, heating, add azodiisobutyronitrile and N- bromo-succinimide, insulation reaction, remove carbon tetrachloride, chemical compounds I and toluene are added thereto, stirring, ethylenediamine is added dropwise simultaneously, cesium carbonate, the mixed liquor of triethylamine, logical nitrogen deoxygenation, add bis- (2-propynyl) ethers of diethylene glycol, tetrakis triphenylphosphine palladium, cupric iodide, 80 DEG C of reactions, hydrochloric acid is added dropwise to neutrality, red brown solid is precipitated, as described organic ruthenium complex.The invention also discloses application of organic ruthenium complex in preparation treatment gastric cancer medicament, liver-cancer medicine, hypertension drug, prepare new drug for research and development and provide experimental data foundation. |
| priorityDate | 2018-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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