http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020989-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D493-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D493-04 |
| filingDate | 2018-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2019-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109020989-B |
| titleOfInvention | Synthesis method of trifluoromethyl substituted 2-methyl dihydrofuran chroman skeleton compound |
| abstract | The invention develops a simple reaction of 2-methyl dihydrofurochroman derivatives and trifluoroacetonate under the catalysis of Bronsted acid, and realizes C (sp) in a 2-methyl form 3 ) -H functionalization, the resulting trifluoromethyl modified 2-methyl dihydro chroman compound is obtained in good yield and excellent diastereoselectivity. The method realizes unique and efficient regioselectivity control, has the advantages of mild reaction conditions, high reaction speed, high yield, no metal, simple operation, good selectivity, good substrate universality and the like, and provides important experimental basis and theoretical basis for modification of 2-methyldihydrofuranchroman compounds. The invention synthesizes a novel skeleton compound with methyl-substituted trifluoromethyl group and chroman structure through molecular design and optimization. |
| priorityDate | 2018-08-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.