| abstract |
The present invention relates to a class of heterocyclic compounds, pharmaceutical compositions containing them, their preparation methods, and their use as mitogen-activated protein kinase-interacting kinase 1 and 2-MNK1/MNK2 inhibitors. The inhibitor is a heterocyclic compound represented by formula (I), or a pharmaceutically acceptable salt, prodrug, solvate, polymorph, isomer, stable isotope derivative, or a pharmaceutical composition containing it . The compounds involved in the present invention can be used to treat or prevent related diseases mediated by MNK, such as cancer. |