| abstract |
The invention belongs to the technical field of chemistry, and in particular relates to a histone deacetylase HDAC6 inhibitor and a preparation method and application thereof. The general structural formula of the inhibitor is: Wherein, X=C or N; R 1 is or R 2 is (CH=CH) n CONHOH or (CH=CH) n CO 2 CH 3 ; n=0 or 1. The compound of the present invention has obvious inhibitory effect on HDAC6; has a protective effect on H 2 O 2 -induced PC12 cell oxidative damage, can inhibit Cu 2+ -induced Aβ aggregation, and has a significant effect on Cu 2+ -induced Aβ aggregates aggregation. Therefore, the compounds of the present invention can be used for the prevention and treatment of Alzheimer's disease and related neurodegenerative diseases. |