http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020875-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D211-90 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D211-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 |
| filingDate | 2018-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109020875-B |
| titleOfInvention | Dihydropyridine compound dehydroaromatization method and application thereof in drug detection |
| abstract | Relates to a dehydroaromatization method of dihydropyridines compounds and application thereof in drug detection, wherein the compounds are, for example, nifedipine, amlodipine, cilnidipine, lacidipine, felodipine, nicardipine, nitrendipine, nimodipine and barnidipine, and the like, and the method is realized by carrying out oxidation reaction in an acidic aqueous solution in the presence of a nickel-containing catalyst and then purifying. The method can be used for preparing impurity reference substances for drug detection and quality monitoring, can also be used for providing reference for design of instruments used in the drug quality detection process, such as a dissolution instrument, and provides reference for design of a drug synthesis process and a preparation production process so as to avoid introduction of impurities through process channels, and can also provide reference for design of a related synthesis process route of dihydropyridine compounds. The reaction can be carried out in an acidic aqueous solution by taking a proper oxidant (such as air) as the oxidant, and carrying out dehydroaromatization reaction at normal temperature and normal pressure in the presence of nickel, the reaction condition is mild, the conversion rate of the target compound is high, the operation is simple and convenient, the byproducts are few, the environmental pollution is small, and the preparation method is completely an environment-friendly preparation process. |
| priorityDate | 2018-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 123.