http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109020835-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C245-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C255-50 |
| filingDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109020835-B |
| titleOfInvention | A kind of preparation method of pharmaceutical intermediate sartanbiphenyl |
| abstract | The invention relates to a preparation method of a pharmaceutical intermediate sartanbiphenyl, the reaction is carried out in a microreactor, and the reaction steps are as follows: (1) p-toluidine is subjected to a diazotization reaction in a first reaction zone to generate a diazonium salt (2) diazonium salt generates sartan biphenyl with benzonitrile in the second reaction zone in the presence of alkali; wherein in step (2) reaction, with cuprous iodide (CuI) as catalyzer, the total reaction time does not more than 10 minutes. The method has the advantages of easily available raw materials, low cost, high selectivity and high yield of the target product, and short reaction time, thereby greatly improving the reaction efficiency. |
| priorityDate | 2018-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.