| abstract |
The invention provides an anti-influenza virus compound, which is a benzoic acid derivative. Compared with the active compound currently on the market, the active compound of the present invention has no chiral center, and the synthesis is simpler; at the same time, the raw material is simple and easy to obtain, and the market supply Many, low prices. The compound of the present invention has been proved by in vitro neuraminidase-specific fluorescent substrate 2'-4-methylumbelliferone-a-N-acetylneuraminic acid experiment, while having strong anti-H3N2 influenza activity, it also has strong anti-H3N2 influenza activity. It has anti-H1N1 influenza activity, and even has a good therapeutic effect on type B influenza, and is expected to be developed as an anti-influenza virus drug. The preparation method of the invention is simple and suitable for industrial production. |