http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109010837-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-635 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H13-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-635 |
| filingDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109010837-B |
| titleOfInvention | Celecoxib composition with high solubility |
| abstract | The invention discloses a celecoxib composition with high solubility, which comprises 50 percent of celecoxib and 50 percent of water-soluble excipient, wherein the water-soluble excipient comprises 1 to 3 percent of moisturizer, 80 to 90 percent of filler and 6 to 15 percent of adhesive; the moisturizer replaces the existing lauryl sodium sulfate, the macrolide with stable structure is formed by esterification of maleic anhydride and lactose, 2 molecules of sodium sulfite are introduced into the macrolide through sulfonation reaction, the hydrophilicity can be carried out through an inner ring and an outer ring in an all-round way, amphiphilic molecules in the moisturizer structure are adsorbed on the celecoxib to form an adsorption layer in directional arrangement, the interfacial free energy is reduced, the wettability of the surface of the celecoxib is effectively changed, the celecoxib is promoted to disintegrate, the solubility and dissolution rate of the celecoxib are greatly increased, and the method has important significance for developing novel oral and injection drug formulations of the celecoxib. |
| priorityDate | 2018-10-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 68.