http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109010831-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K41-0038 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7088 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 |
| filingDate | 2018-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-12-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109010831-B |
| titleOfInvention | Application of LncRNA RET in regulation of tumor cell radiosensitivity |
| abstract | The invention discloses application of LncRNA RET in regulation of tumor cell radiosensitivity. The invention provides an application of RET related biological materials in preparing products for regulating and controlling the radiation sensitivity of tumor cells; the RET-associated biological material is RET or a substance capable of promoting/inhibiting the expression of RET. The down regulation of RET expression can inhibit the growth of tumor cells under radiation pressure and increase the radiation sensitivity of the tumor cells, and the possible mechanisms are promoting the apoptosis of the tumor cells caused by radiation, reducing the DNA damage repair caused by radiation and reversing the epithelial-mesenchymal transition of the tumor cells caused by radiation. RET regulates the radiosensitivity of tumor cells by modulating PTEN. Under radiation pressure, PTEN can reverse the growth, apoptosis increase, DNA damage repair and EMT generation of tumor cells caused by RET silencing, thereby regulating the radiosensitivity of the tumor cells caused by RET. |
| priorityDate | 2018-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 382.