http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-109010324-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-7007 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-10 |
| filingDate | 2018-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-07-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-109010324-B |
| titleOfInvention | Sildenafil oral dissolving film agent and preparation method thereof |
| abstract | The invention relates to a sildenafil orally dissolving film agent and a preparation method thereof, wherein the orally dissolving film agent comprises a pharmaceutical active ingredient, a water-soluble high polymer film forming material, a plasticizer and a flavoring agent, the pharmaceutical active ingredient is sildenafil citrate and/or pharmaceutically acceptable salts thereof, and the water-soluble high polymer film forming material is any one or the combination of at least two of hydroxypropyl cellulose, pullulan, hydroxypropyl methylcellulose or polyvinylpyrrolidone. The preparation method of the orally dissolving film agent comprises the steps of mixing a flavoring agent, a water-soluble polymer film forming material and a plasticizer in a solvent, adding a pharmaceutical active ingredient into the mixture, dispersing the mixture to obtain a pharmaceutical solution, and then carrying out film forming treatment to obtain the orally dissolving film agent. The sildenafil oral dissolving film agent provided by the invention has the advantages that no medicine is separated out under the condition of high medicine loading rate, and the sildenafil oral dissolving film agent still has good mechanical properties and mouthfeel, and simultaneously has low hygroscopicity and good film removing performance. |
| priorityDate | 2018-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.