http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108997429-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-4006 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 |
| filingDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-10-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108997429-B |
| titleOfInvention | Method for preparing Beciclovir |
| abstract | The invention relates to a method for preparing P- [ [ [1- [ (2-amino-9H-purine-9-yl) methyl ] methyl]Cyclopropyl group]Oxy radical]Methyl radical]-a process for phosphoric acid (Besifovir ), comprising: 1) reacting a compound of the following formula (1) Reacting with tert-butyldiphenylchlorosilane to prepare a compound shown in the following formula (2), 2) the compound of formula (2) is reacted with ethylmagnesium bromide to prepare the following formula (3) in a solid form, 3) the compound of formula (3) is reacted with diethyl p-toluenesulfonyloxymethylphosphonate under the condition of taking lithium tert-butoxide as a base to prepare the following formula (23), 4) the compound of formula (23) is hydrolyzed with ammonium fluoride to produce the following formula (24), 5) reacting a compound of formula (24) with a compound of formula (28) to prepare a compound of formula (22) below in solid form, 6) the compound of formula (22) is reductively dechlorinated under the conditions of a catalyst and a hydrogen donor to produce the following formula (25) in a solid form, 7) the compound of the formula (25) is hydrolyzed by trimethyl bromosilane to prepare the Behcovir of the following formula (9), the method has the advantages of cheap and easily-obtained raw materials and intermediate materials, low cost, high yield, mild conditions and good safety. |
| priorityDate | 2018-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 70.