http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108997428-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07F9-65616 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C65-21 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-675 |
| filingDate | 2018-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108997428-B |
| titleOfInvention | Co-crystal of tenofovir alafenamide and vanillic acid and preparation method thereof |
| abstract | The invention discloses a tenofovir alafenamide and vanillic acid eutectic crystal and a preparation method thereof. The structural formula of the eutectic is as follows: in the eutectic, the molar ratio of tenofovir alafenamide to vanillic acid is 1: 1. Also discloses a preparation method of the eutectic crystal and application of the eutectic crystal. The tenofovir alafenamide-vanillic acid eutectic provided by the invention has higher melting point, improved thermal stability and improved hygroscopicity, reduces the sensitivity to environmental humidity and temperature in the preparation and storage processes, simplifies the production and post-treatment processes of medicines, reduces the material storage and quality control cost, has stronger economic value, and is more suitable for being used as a raw material medicine. In addition, the crystal has good crystallinity, is easy to prepare and is suitable for industrial large-scale production. |
| priorityDate | 2018-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.