http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108997236-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D249-08 |
| filingDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-09-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108997236-B |
| titleOfInvention | Preparation method of anastrozole impurity |
| abstract | The invention belongs to the technical field of chemical synthesis, and particularly relates to a preparation method of anastrozole impurities. The invention takes 5-methyl-1, 3-benzene diacetonitrile as raw material, and obtains anastrozole impurity through methylation reaction, substitution reaction, N-halogenated succinimide free radical reaction and nucleophilic substitution reaction: the invention discloses a preparation method of 2, 3-bis (3- (1-cyano-1-methylethyl) -5- (1H-1,2, 4-triazole-1-methyl) phenyl) -2-methylpropanenitrile, and the preparation method has the characteristics of short synthetic route, simple and convenient operation, high purity of the obtained product, convenience for reference substance research and the like. The preparation method has great significance for researching the impurities of the anastrozole, and can be used for qualitative and quantitative analysis of the impurities in the anastrozole production, so that the quality standard of the anastrozole is improved, and important guiding significance is provided for safe medication. |
| priorityDate | 2018-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.