| abstract |
The invention belongs to the technical field of chemical preparation, and particularly relates to a difluoromethylation reagent and preparation and application thereof. Aiming at the key problem that the stability of the electrophilic difluoromethylation reagent is poor at present, the problem of the stability of the reagent is solved through innovative design. Synthesizing to obtain an electrophilic difluoromethylation reagent which is stably preserved at room temperature; can meet the difluoromethyl functionalization of different types of substrates, and develop a plurality of new difluoromethylation methods and new reactions. And the reagent is solid, the use and the operation are simple and convenient, and the operability is high. |