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filingDate 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2022-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber CN-108997089-B
titleOfInvention Method for catalyzing arylation of benzyl alcohol compound
abstract The invention belongs to the field of organic synthesis, and discloses a method for catalyzing arylation of a benzyl alcohol compound, which comprises the steps of mixing the benzyl alcohol compound with an aryl compound, adding a solvent and a catalyst of trifluorophenylborane, and reacting for 4-8 hours at 60-120 ℃ to obtain a benzyl alcohol arylation product. The reaction realizes dehydration and arylation reactions on a series of benzyl alcohols by using the trifluoropentafluorophenylborane as a catalyst, and the reaction can quickly construct triarylmethane compounds and organic small molecules containing a plurality of heterocycles, which have important significance in drug molecules. The method is simple to operate, high in reaction efficiency and diverse.
priorityDate 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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