http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108949783-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-523 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-74 |
classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-32 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-35 |
filingDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2021-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-108949783-B |
titleOfInvention | Recombinant BCG vaccine and application thereof |
abstract | The invention relates to the field of genetic engineering and the technical field of tuberculosis vaccines. The invention provides a recombinant BCG vaccine containing related coding genes of a mycobacterium tuberculosis genome RD4 region. It is recombinant BCG vaccine formed by transforming recombinant colibacillus-mycobacterium shuttle plasmid containing coding mycobacterium tuberculosis genome RD4 region protein gene into BCG vaccine. The recombinant BCG realizes the expression of genes and proteins in the RD4 region. After animals are immunized, the safety of the recombinant BCG strain including the complete RD4 area is not reduced, and the safety of the recombinant BCG strain including a part RD4 area (Rv1501-Rv1508c) is obviously improved. The recombinant BCG strain containing complete/partial RD4 area gene shows better anti-infection protection effect. The recombinant BCG vaccine can be used for preventing or treating tuberculosis. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114574414-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-114574414-B |
priorityDate | 2017-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 905.