http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108948210-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2319-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2800-22 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K50-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-461 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23K20-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-815 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K50-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23K20-147 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 |
| filingDate | 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2021-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-108948210-B |
| titleOfInvention | Hybrid antibacterial peptide PA-MO and preparation method and application thereof |
| abstract | The invention provides a hybrid antibacterial peptide PA-MO and a preparation method and application thereof. According to the invention, on the basis of carrying out spatial structure analysis on the fish-derived antibacterial peptide parasin I and the moronecidin, the antibacterial peptide parasin I and the moronecidin are spliced, a protein linker is added in the middle, and amino acid mutation at partial sites is carried out simultaneously, so that a novel hybrid antibacterial peptide PA-MO is obtained, and the antibacterial effect of the novel hybrid antibacterial peptide PA-MO is obviously improved. The heterozygosis antibacterial peptide PA-MO gene is artificially synthesized after optimized pichia pastoris preferred codon, and is cloned in pichia pastoris for expression, and the antibacterial efficacy of the heterozygosis antibacterial peptide PA-MO obtained through recombination expression is obviously improved compared with that of the original antibacterial peptide. The fermentation scale of the recombinant strain is enlarged to the level of a fermentation tank, and the fermentation liquor can be further purified to prepare an antibacterial peptide preparation for preventing and treating aquatic animal diseases. |
| priorityDate | 2018-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.